I think big pharma is a major contributor to PBS, and it showed. They did a better job than most similar segments on the ethical issues involved, and the presentation of the parents was quite effective. Surely the very success of vaccine programs, the absence of mumps, measles, and polio over the past generation gives young parents a different perspective from their parents and grandparents. But as most similar presentations do, this one exaggerated the role vaccines have played in reducing the incidence of disease. Nor did it show what is making parents hysterical. It did not pay any attention to the increase in autism diagnoses. Is the increase simply a statistical artifice, the result of better and earlier diagnosis? I don't think anyone knows. The show failed to look carefully at the epidemiological studies they cited. I haven't followed the debate closely since the IOM report on autism came out in 2004: the handful of studies it relied on were all obviously flawed. Getting reliable data sets and doing this kind of work on vaccines is extremely difficult. It's not that I think the parents are right or that there is a link between vaccines and autism. I'm with VLM that these parents have no idea what's best for themselves or their children. I am glad I do not live in the part of Oregon the show presents, where whole communities are opting out of vaccine programs. If nothing else, the neighbors would drive me crazy. But I do think parents have provoked the medical establishment behave badly in order to protect the vaccine program. I notice the show didn't breath a word of the Simpsonwood transcripts, the most troubling evidence I've come across. In June 2000, the CDC National Immunization Program called together a team of consultants, state and federal public health officials, and pharma reps to deal with preliminary findings from the CDC's own lead statistician, who said he couldn't make an association between thimerisol (a mercury-based preservative) and autism go away. One of the doctors there got a call in the middle of the proceedings from his daughter-in-law. She had just delivered the first son in the next generation. He said he was so troubled by what he saw that he told her not to let his new grandson have any vaccines with thimerisol until scientists could figure out what was going on. At the end of the session, when the group rated the probability of a relationship between thimerisol and neurological problems, most of them dismissed the connection. The one lone holdout (a different doctor!) got berated in front of all of them for jeopardizing the vaccine program. Science has no doubt improved at an impressive pace recently, but to suggest that scientists and statisticians are immune from political bias, that politics plays no role in science, that Paul Offit is a disinterested expert, would be naive. I have no idea where the science is at this point. By all appearances, the CDC flooded the data set that produced the initial results, and I really haven't followed it further. Autism certainly hasn't gone away. I also thought the show could have done a better job presenting arguments that the vaccine schedule itself might pose risks. They mention the claim but then immediately drop it. The number of vaccines given to very young children has increased dramatically in the past generation, a perverse, last gasp response, I think, to the collapse of Great Society social programs. As social programs go, vaccination is both affordable to the public and yet handsomely profitable to big pharma at the same time. We vaccinate one-day-old infants against sexually transmitted diseases not because they are likely to contract those diseases but because so many of them will never see a doctor again. Vaccines can be tested individually, with difficulty, but how do we evaluate the consequences of giving so many in rapid succession at such a young age? Are there no trade-offs in increasing coverage rates by compressing the schedule as we do? I have heard credentialed doctors and scientists argue over the question, but they were absent here.