From the older list a few years back, it remains hard to go wrong with Supino for pizza or Astro for coffee and a small cafe lunch/breakfast.
I'll thank Ken for the recommendation of checking out Selden Standard. Sounds like you're already planning on coming, which is wonderful to hear. Obviously, I think we do a nice job, but please let me know what you think. We just ran out of all our absurdly low priced older vintages of Bordeaux, but we'll have some other fun stuff. I'll be on my way to the west side of the state when you're here, so don't think me rude when I inevitably don't say hi.
A bit different in style but with a similar local farm influence is Chartreuse Kitchen. They've got a decent wine list these days, good bartenders, etc, but they also have a reasonable corkage.
If Katoi is re-opened (closed for several months from a fire) by the time you get here, you should check that out -- Thai and Laotian style food with a few Midwestern riffs here and there. Wine program is fine, cocktails better. [EDIT 6/27 - SCRATCH THIS... They're saying they'll be open in mid/late July from what I can tell]
I'll second Steve's recommendation of Motor City Wine, especially on nights when they've got some live music.
If you want to hit up southwest Detroit, there are more interesting options now than I've had a chance to visit, but El Asador remains a favorite, and you can bring your own bottle.
If you're on the go and need a coffee or want to take some beans or tea back home, Anthology Coffee is a great stop. Very unassuming, great stuff (we use it at the restaurant), and they also resell Joseph Wesley Teas, which are traditional Chinese teas that a friend of mine selects himself from farmers he knows over there. (Long story, but he spent a lot of time in China and grew infatuated with tea... brings in some great, classic teas.)
Keep your eyes peeled for any shows at Third Man Records. I think people associate it with a record shop, and they've brought some good acts through there with zero lines, etc. Other venues to look at (more for rock or electronic) would be Marble Bar, El Club, and UFO Factory.
You might wander around a bit downtown just to see the transformation that's happened between the Fox Theater and the river. You could grab some wine or food at Wright & Company, a glass or bottle of wine at The Royce (wine bar with a wide ranging selection and a super nice owner), and just see the visual transformation if nothing else. Also downtown... one of the best spots for cocktails, a place called Standby.
If you happen to be in Eastern Market, Cairo Coffee does a good job, and if you wander around a bit, you'll find that most (or at least many) of the buildings have been adorned in some pretty sweet murals from local artists.
SORRY for not including links... I'm rushing through this on my way to a meeting and then off to a wine tasting. Enjoy your trip!