NWR: How mRNA vaccines happened so fast

originally posted by politburo:
originally posted by Oswaldo Costa:
originally posted by Otto Nieminen:
btw, who runs this place these days? I tried to change my name here but politburo never replied to my message. How do I get in touch with the current politburo?

Like every administration that needs to replace profit with other kinds of motivation, the Politburo is a stickler for proper procedure, but it should work if you send them a scan of your new passport showing the name change.

He’ll always be Otto to us.

is this another maddening example of otto-correct?

grrrr. . . .
 
Referring back to the vaccine (imagine that?), there are reports of cases of reactions to the vaccine...one hospital temporarily ceased their inoculations.

. . . . . Pete
 
originally posted by Peter Creasey:

Referring back to the vaccine (imagine that?), there are reports of cases of reactions to the vaccine...one hospital temporarily ceased their inoculations.

. . . . . Pete

Well, if they were inoculating, that may be the reason. These are vaccines, after all.
 
originally posted by Peter Creasey:

Referring back to the vaccine (imagine that?), there are reports of cases of reactions to the vaccine...one hospital temporarily ceased their inoculations.
There have been two bad reactions (anaphylaxis) in Alaska. No one has stopped administering the vaccine for any significant period.
 
Interesting feature about Team Biologics, the team FDA sends to inspect vaccine production in Vanity Fair. With internal memos and downgrading of any inspection reports, wonder how sterile the production is on these newfangled COVID vaccines?
 
originally posted by MarkS:
Interesting feature about Team Biologics, the team FDA sends to inspect vaccine production in Vanity Fair. With internal memos and downgrading of any inspection reports, wonder how sterile the production is on these newfangled COVID vaccines?

So now even Vanity Fair is producing vaccines?
 
originally posted by Oswaldo Costa:
originally posted by MarkS:
Interesting feature about Team Biologics, the team FDA sends to inspect vaccine production in Vanity Fair. With internal memos and downgrading of any inspection reports, wonder how sterile the production is on these newfangled COVID vaccines?

So now even Vanity Fair is producing vaccines?

Here comma comma
 
Every vaccine ever made has caused a few allergic, even anaphylactic, reactions in recipients. The buzz is that the 2 in the UK at least may have been to PEG in the preparation. Speaking personally, my upper arm was a bit unhappy about being converted into a spike protein factory for a day or so but nothing else. I'm told the booster can be a bit more than that... or not. Seems a small price to pay.

To wit:
 
I think this is the money quote from the Huffpost article (and it has been reported elsewhere, but not yet in the Gray Lady, so maybe it isn't as important as Hillary's emails.)

The biggest takeaway is that while the vaccines differ in how well they prevent symptomatic disease, so far nobody who has taken any of these vaccines have died or been hospitalized due to COVID-19. Preventing severe disease is something all the shots do well, so even imperfect vaccines will prove invaluable in our quest to end the pandemic.
 
originally posted by Andrew Zachary:
I think this is the money quote from the Huffpost article (and it has been reported elsewhere, but not yet in the Gray Lady, so maybe it isn't as important as Hillary's emails.)

The biggest takeaway is that while the vaccines differ in how well they prevent symptomatic disease, so far nobody who has taken any of these vaccines have died or been hospitalized due to COVID-19. Preventing severe disease is something all the shots do well, so even imperfect vaccines will prove invaluable in our quest to end the pandemic.

The Washington Post had an op ed column to the same effect this morning, arguing that this is the most significant result. I would agree. If the vaccines mean that catching Covid will be like catching a seasonal flu, that would be a pretty good outcome.
 
We didn't have a choice of vaccines so, obviously, we grabbed the first one that came available to us (Pfizer in our case). Both Pfizer shots only caused minor reactions.

VERY large numbers of cars and people were present, but the administrations were so well-organized that it didn't take long at all. (Hopefully, the hyphenation was appropriate.)

. . . . . Pete
 
originally posted by Jonathan Loesberg:
originally posted by Andrew Zachary:
I think this is the money quote from the Huffpost article (and it has been reported elsewhere, but not yet in the Gray Lady, so maybe it isn't as important as Hillary's emails.)

The biggest takeaway is that while the vaccines differ in how well they prevent symptomatic disease, so far nobody who has taken any of these vaccines have died or been hospitalized due to COVID-19. Preventing severe disease is something all the shots do well, so even imperfect vaccines will prove invaluable in our quest to end the pandemic.

The Washington Post had an op ed column to the same effect this morning, arguing that this is the most significant result. I would agree. If the vaccines mean that catching Covid will be like catching a seasonal flu, that would be a pretty good outcome.

Flu deaths (hard to measure exactly, but the best estimates) are in the tens of thousands per year, so maybe like a bad cold but not the flu.
 
THe column said seasonal flu. And while there are a lot of flu deaths, the flu vaccine, which does not always prevent infection, does reduce serious infection and death from it, though it doesn't seem to eliminate it entirely. It is that outcome to which I was referring. Really, hoping Covid would become like the common cold may be a bridge too far.

Except maybe for teachers. Once I had been teaching for ten years, I became pretty much impervious to flu and rarely had colds, and none that lasted more than a couple of days. It's not a type of immunity that I would recommend, though. Those first ten years were a constant series of cuughs, sneezes and sniffles. And many of my colleagues don't seem to acquire it.
 
originally posted by Jonathan Loesberg:
Except maybe for teachers. Once I had been teaching for ten years, I became pretty much impervious to flu and rarely had colds, and none that lasted more than a couple of days. It's not a type of immunity that I would recommend, though. Those first ten years were a constant series of cuughs, sneezes and sniffles. And many of my colleagues don't seem to acquire it.

While you may have built up antibodies to some rhinovirus and coronavirus that cause what we refer to as the "common cold" you did not become impervious to influenza A or B. New strains circulate every year. Sometimes your b-cells may be able to have an affect against a different variant, every year is a new influenza virus which is why we need a vaccine every year. It may be that this is how the new corona virus will behave going forward, that is, we will need a seasonal vaccine. However, because the new vaccines are so effective, we *might* be able to wash it out of circulation if we can get worldwide vaccination rates high enough.

The good news is that the SARS-CoV-2 vaccines seem to confer protection from severe disease even in the new variants even if they are less effective in their current for at preventing infection for some of the new variants (specifically the SA variant, the B.1.351 lineage).
 
I can't say you are wrong since I am insufficiently knowledgeable. It remains the case that I don't get the flu and didn't start getting shots until relatively recently.
 
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